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Stabilizing dose-response of anticoagulants

Epitome has unraveled the dose-response algorithm for warfarin and other coumarins. Patients’ dose-response curves are stable as long as their medical condition is the same; we can detect shifts of as little as 10% of dose when they receive an interfering drug, and therefore provide guidance for a new optimum dose. The algorithm derives the patient-specific parameters for sensitivity to coumarins, their optimum dose, the time their bodies take to respond to dose changes and their inherent variability. These parameters are obtained by de-convoluting and fitting the patient’s own INR/dose history.

Controlling the effects of prophylactic anti-coagulation is a serious medical issue with approximately 3 million patients in the US on trial and error dose adjustment regimes. Managing anticoagulation consumes vast amounts of clinic time, and hospital time when overdoses result in bleeding. The costs of venous thromboembolism to the US healthcare system are estimated as $15 – 34 billion annually (Thromb Haemost;108(2):291-302. (2012) PM:22739656). Per patient costs for those with a diagnosis of venous thromboembolism are estimated as $16,000 per year higher than those without this diagnosis (J Manag Care Pharm. 2012 Jun;18(5):363-74 PM:22663169).

Patient-specific Warfarin dosing nomogram
Fearon Nomogram (patient-centered format) for Patient #23.


The Epitome system generates a patient-specific dosing nomogram. The nomogram displays the dose that will keep the patient within the optimal INR range, as well as high and low dose adjustment to return the patient to the optimal range. The INR measurement is naturally variable, so we recommend retesting an out-of-range INR before changing the dose. When the second INR reading continues to exceed the upper or lower ranges set in the nomogram, a doctor's intervention is necessary. Usually the INR only exceeds these bounds when the patient’s response to warfarin has shifted to a new regime due to a change in medical condition. In that case, a minimum of 4 INR/dose values from the new regime are required to produce a new nomogram.

The sample nomogram here is for a patient with a therapeutic range of 2.0 to 3.0; their natural variability is too high to confine their INR to this narrow window. Should their medical condition change, their INR will shift and the nomogram provides a higher or lower dose accordingly; both of these doses are still predicted to result in an average INR within the therapeutic range. The doctor receives the clinical format of this nomogram with further details.


Fearon Nomogram (clinical format) for Patient #23.


See also:
Inherent INR variability: retesting INR reduces dose changes



Epitome seeks more doctors and clinics interested in testing the Fearon Nomogram System. To find out more about trial design please contact Epitome.


Early Drug Development in cooperation
with the Pharmaceutical Industry